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ENZYME
Optimize all your enzyme properties in the same campaign
Run multi-property optimization across activity, expression, thermostability and anything else you measure — trained on your own assay data. Reach a variant that meets your full target profile in fewer rounds.
Every enzyme engineers knows the pattern…
Your best Round 4 variant has 3× activity — and 40% lower expression. Your +15°C Tm hit doesn't tolerate process pH. The two best single mutants combined perform worse than either parent. And your assay drifted between batches, so half your data is noise.
Directed evolution optimizes one property per round. Rational design from a crystal structure misses the distant positions that drive real-world performance. Combining single winners ignores epistasis.
Cradle was built for teams past the screening hit. The goal is to get you to a variant that holds up at scale.
Enzyme discovery before
Enzyme discovery with Cradle
Move faster from screening hit to scalable enzyme.
Fewer rounds
Stop running dozen-round directed evolution campaigns
Cradle is built to handle the realities of the lab—like assay noise and batch-to-batch variation—that usually stall engineering. Scientists reach target profiles 2-12x faster using as little as one 96-well plate of data. You get to the "winner" faster while spending less on synthesis and screening.
Better enzymes
Optimize for activity, stability, and expression in parallel
Stop choosing between a high-performer that won’t express and a stable lead with no activity. Cradle balances these trade-offs from round one, finding non-intuitive mutations that traditional rational design misses. You get a diverse set of sequences that aren't just "hits" in an assay, but viable candidates for production.
Built for biologists
An intuitive workbench for any enzyme class
Your team can run campaigns directly through a UI that combines 3D structural views with sequence insights—no coding or data science degree required. Whether you’re engineering P450s or polymerases, you maintain full control of the strategy. Most importantly: your sequences and models remain your exclusive IP.
If you can measure it, you can optimize it with Cradle.
Set multiple objectives and let Cradle find variants that balance them - starting from as few as 96 variants per round.
Activity
Catalytic turnover, kcat, specific activity, substrate conversion
Stability
Thermostability (Tm), pH tolerance, solvent tolerance, shelf life
Selectivity
Product selectivity, substrate specificity, enantioselectivity
Application-specific
Fermentation robustness, formulation compatibility
CASE STUDIES
Wet lab validated.
Trusted at industrial scale.
"Through our partnership with Cradle, we are embedding advanced Al directly into how we innovate, enabling our teams to shorten development time and bring real-world biosolutions faster to market."
Same experimental
workflow—better results.
With everyone in the same workspace, results compound across your organization. Same data. Same models. Same learning loop. New results.
Unlimited seats
Better enzymes
starts with Cradle
