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AI-guided vaccine & antigen engineering

Effective, thermostable antigens in fewer rounds.

Get measurable Tm improvements without compromising the immune response — in fewer rounds than traditional rational design. +2.5°C Tm in a single round, 7× faster.

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Antigen optimization means balancing stability, immunogenicity, and expression. Human intuition isn't built for that.

You need the antigen to survive storage and transport, but mutations that improve Tm can disrupt epitope presentation. Stabilize the prefusion conformation, you might tank expression. And if you make the wrong shape, you're not going to have an effective vaccine at all.

Traditional rational design means sequential rounds - first stability, then checking you didn't break immunogenicity, then fixing what you broke. Each cycle takes months, and 54% of Phase 3 trials fail, with more than half attributed to inadequate efficacy.

Vaccine discovery before

Project design

Target ID

Variant generation

Optimization

Application testing

Lead Op

Scale up

Vaccine discovery with Cradle

Project design

Target ID

AI-assisted protein engineering

AI Protein Engineering

Scale up

From unstable antigen to thermostable candidate, faster.

Fewer rounds

Measurable improvement, often in a single round

Cradle balances thermostability, immunogenicity, expression, and manufacturability in parallel — not sequentially. On a S. aureus chimeric antigen, Cradle delivered +2.5°C Tm in a single zero-shot round, 7× faster than the partner's rational design approach. No starting sequence-function dataset required.

Better Antigens

Control conformation, epitope presentation, and stability together

Stabilize prefusion states. Control epitope presentation. Avoid aggregation-prone sequences. Reduce post-translational modification liabilities that compromise scale-up. Cradle generates diverse panels of candidates that balance every property at once, including the antigen-specific properties standard predictors don't handle.

Built for biologists

An intuitive workbench for any enzyme class

Your team can run campaigns directly through a UI that combines 3D structural views with sequence insights—no coding or data science degree required. Whether you’re engineering P450s or polymerases, you maintain full control of the strategy. Most importantly: your sequences and models remain your exclusive IP.

Fewer rounds

Measurable improvement, often in a single round

Better Antigens

Control conformation, epitope presentation, and stability together

Built for biologists

An intuitive workbench for any enzyme class

Supported properties

If you can assay it, Cradle can optimize for it.

Optimize multiple properties simultaneously - stability, immunogenicity, and yield in every round.

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Immunogenicity

Epitope presentation, conformation (prefusion/postfusion), neutralizing antibody response

Stability

Thermostability (Tm), aggregation resistance, shelf life, storage stability

Manufacturability

Expression yield, solubility, post-translational modification compatibility

Formulation

Lyophilization compatibility, glass transition temperature (Tg)

CASE STUDIES

6 of the top 25 pharma companies already use Cradle.

Case studies

Improving Staphylococcus aureus vaccine thermostability by 2.5 °C in a single round, 7× faster than rational design

Case studies

Improving Staphylococcus aureus vaccine thermostability by 2.5 °C in a single round, 7× faster than rational design

"Cradle's platform provides us with scalable scientist-centric solutions to maximize the opportunities in our biologics portfolio and potentially deliver faster, more effective medicines to patients."

Anastasia Hager, Ph.D.

Global Head of Drug Discovery Sciences, Bayer

Same experimental workflow.
Better results.

With everyone in the same workspace, results compound across your organization. Same data. Same models. Same learning loop. New results.

API and Web Interface

Granular access controls

Unlimited seats

Web Interface

For wet lab scientists

Add your domain expertise and AI generate candidates for lab testing in just a few clicks. Upload experimental results to improve your project-specific AI automatically.

Learn more about the Cradle platform

API Access

For computational teams

Run Cradle with an API and scale your expertise without the DevOps overhead. Focus on novel design strategies, not routine requests and endless configuration.

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