AI-guided antibody Development
Make your complex biologics happen.
Get to clinically viable antibody candidates faster. Meet every property in your TPP, with fewer programs lost along the way.
The next generation of biologics needs more than affinity
Your team is being asked to deliver biologics with binding profiles, formats, and developability constraints that single-property optimization can't reach. Bispecifics that hold both arms together at temperature. ADCs that survive payload conjugation without aggregating. Multispecifics with humanness, low immunogenicity, and clean PK. Hard targets where binding is only step one.
Antibody development before
Antibody development with Cradle
Move faster from screening hit to scalable antibody.
Fewer rounds
Reach your full target product profile 2-12x faster
Cradle optimizes binding, stability, developability, and manufacturability in parallel — not sequentially. Bring immunogenicity, toxicity, and functional assay data into the loop from round one.
Better Antibodies
Explore sequence space your intuition wouldn't reach.
Diverse panels of candidates with non-intuitive mutations rational design and display campaigns wouldn't surface. Sequences close to germline, free from immunogenic motifs and PTM liabilities. Across VHH, scFv, Fab, IgG, bispecifics, and antibody-drug conjugates.
Built for scientists
An intuitive workbench for antibody scientists
Scientists run campaigns directly through the UI. Computational teams extends the platform via API with their own predictors and scoring. Your sequences and model weights stay yours.
Selected properties
If you can measure it, you can optimize it with Cradle.
Set multiple objectives and let your team's project-specific model find candidates that balance them.
Binding
KD, kon, koff, specificity, cross-reactivity, pH-dependent binding
Stability
Thermostability (Tm), aggregation, viscosity
Manufacturability
Expression yield, hydrophobicity (HIC)
Immunogenicity
Humanness, T-cell epitope risk, MHC binding
Developability
PTM liabilities (isomerization, deamidation, oxidation), polyspecificity
CASE STUDIES
8 of the top 25 pharma companies already use Cradle.
"Cradle's platform provides us with scalable scientist-centric solutions to maximize the opportunities in our biologics portfolio and potentially deliver faster, more effective medicines to patients."
Unlimited seats
Web Interface
For scientists
Add your domain expertise and AI generate candidates for lab testing in just a few clicks. Upload experimental results to improve your project-specific AI automatically.
API Access
For computational teams
Run Cradle with an API and scale your expertise without the DevOps overhead. Focus on novel design strategies, not routine requests and endless configuration.
Ready to get to clinical faster?
Talk to the Cradle team.
