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AI-guided Peptide engineering
Optimize peptides without protein-scale data.
Cradle learns from small datasets and tight sequence constraints — getting you to candidates that meet all your requirements, even starting late in development.
Peptides aren't just small proteins. Your tools shouldn't treat them like they are.
Standard predictors for solubility, aggregation, and stability? Built for proteins. Public databases? Sparse on peptides. And peptide optimization comes with constraints other protein engineering campaigns don't face: cyclization, non-standard amino acids, linker dependencies, and late-stage programs where sequence flexibility is minimal and you need to hit multiple properties at once.
Cradle helps scientists engineer better peptides faster by learning from your in-house assay data and building project-specific models for your specific peptide.
Peptide discovery before
Peptide discovery with Cradle
Move faster from a weak lead to a candidate clearing every constraint.
Fewer rounds
Multi-property optimization with peptide-scale data
Balance binding, metabolic stability, solubility, and developability in a single campaign. Cradle builds fit-for-purpose models from as few as 96 data points.
Better peptides
Reach peptides that clear tight, simultaneous constraints
Cradle reaches peptide variants that rational design and screening miss, and holds tight constraints while it does. In three stalled programs at a top-20 pharma, at least half of each designed library met all four targets at once: potency, specificity, expression, and stability.
Built for scientists
An intuitive workbench for any peptide format
Cyclic peptides, staples, bicycles, peptide-drug conjugates, masked linkers — handled natively in the UI. Your team runs campaigns directly, no coding required. Your sequences and models stay your exclusive IP.
If you can assay for it, you can optimize it with Cradle.
Set multiple objectives and let Cradle find variants that balance them — starting from as few as 96 variants per round.
Potency
EC50, IC50, KD, on-rate, off-rate, receptor activation
Selectivity
Off-target binding, receptor specificity, cross-reactivity
Stability
Metabolic stability, plasma half-life, proteolytic resistance, thermostability (Tm)
Developability
Expression, solubility, aggregation, synthetic accessibility
CASE STUDIES
Trusted by 8 of the top 25 pharma companies and industrial R&D leaders.
"Cradle's platform provides us with scalable scientist-centric solutions to maximize the opportunities in our biologics portfolio and potentially deliver faster, more effective medicines to patients."
Anastasia Hager, Ph.D.
Global Head of Drug Discovery Sciences, Bayer
Unlimited seats
Web Interface
For peptide engineers
Add your domain expertise and AI generate candidates for lab testing in just a few clicks. Upload experimental results to improve your project-specific AI automatically.
API Access
For computational teams
Run Cradle with an API and scale your expertise without the DevOps overhead. Focus on novel design strategies, not routine requests and endless configuration.
Better peptides. Faster.
Talk to the Cradle team.
